Estudios  científicos

[1] Amulic, Borko, Christel Cazalet, Garret L. Hayes, Kathleen D. Metzler, and Arturo Zychlinsky. "Neutrophil Function: From Mechanisms to Disease." Annual Review of Immunology Annu. Rev. Immunol. (2012): 459-89 

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[2] Lehne, G., Haneberg, B., Gaustad, P., Johansen, P. W. et al., Oral administration of a new soluble branched β-1,3-D-gluccan is well tolerated and can lead to increased salivary concentrations of immunoglobulin A in healthy volunteers. Clin. Exp. Immunol. 2005, 143, 65–69. 

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[3] Kohl, A., Gogebakan, O., Mohlig, M., Osterhoff, M. et al., Increased interleukin-10 but unchanged insulin sensitivity after 4 weeks of (1,3)(1,6)-beta-glycan consumption in overweight humans. Nutr. Res. 2009, 29, 248–254. 

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[4] Kirmaz, C., Bayrak, P., Yilmaz, O., Yuksel, H., Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur. Cyto. Network 2005, 16, 128–134. 

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[5] Talbott, S., Talbott, J., Effect of beta 1, 3/1, 6 glucan on upper respiratory tract infection symptoms and mood state in marathon athletes. J. Sport Sci. Med. 2009, 8, 509–515. 

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[6] Feldman, S., Schwartz, H. I., Kalman, D. S., Mayers, A. et al., Randomized phase II clinical trials of Wellmune WGP(R) for immune support during cold and flu season. J. Appl. Res. 2009, 9, 30–42. 

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[7] Talbott, S., Talbott, J., Beta 1,3/1,6 glucan decreases upper respiratory tract infection symptoms and improves psychological well-being in moderate to highly-stressed subjects. Agro Food Ind. Hi. Tec. 2010, 21, 21–24. 

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[8] Fuller, R., Butt, H., Noakes, P. S., Kenyon, J. et al., Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections. Nutrition 2012, 28, 665–669. 

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[9] Graubaum, H.-J., Busch, R., Stier, H., Gruenwald, J., A double-blind, randomized, placeob-controlled nutritional study using an insoluble yeast beta-glucan to improve the immune defense system. Food Nutr. Sci. 2012, 3, 738–746. 

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[10] Auinger, A., Riede, L., Bothe, G., Busch, R. et al., Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects. Eur. J. Nutr. 2013, doi: 10.1007/s00394-013-0492-z.

[ 11 ] Maggini, S, Wenzlaff, S, Hornig, D: Essential role of vitamin C and zinc in child immunity and health. J Int Med Res 2010; 38: 386–414.  https://doi.org/10.1177/147323001003800203

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[12 ] Wintergerst, ES, Maggini, S, Hornig, DH: Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab 2006; 50: 85–94.

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[13] S Maggini, S Beveridge, M Suter. A Combination of High-Dose Vitamin C plus Zinc for the Common Cold. February 1, 2012. https://doi.org/10.1177/147323001204000104

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[14] Stefanidou, M., Maravelias, C., Dona, A. et al. Zinc: a multipurpose trace element. Arch Toxicol 80, 1 (2006).  https://doi.org/10.1007/s00204-005-0009-5

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[15] Salgueiro, M.J., Zubillaga, M., Lysionek, A. et al. Zinc status and immune system relationship. Biol Trace Elem Res 76, 193–205 (2000). https://doi.org/10.1385/BTER:76:3:193

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[16] Singh  M, Das  RR. Zinc for the common cold. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD001364. DOI: 10.1002/14651858.CD001364.pub4. Accessed 24 August 2021.

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[17] Ströhle A, Hahn A. Vitamin C and immune function. Medizinische Monatsschrift fur Pharmazeuten. 2009 Feb;32(2):49-54; quiz 55-6. PMID: 19263912.

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[18] Kennes B, Dumont I, Brohee D, Hubert C, Neve P: Effect of Vitamin C Supplements on Cell-Mediated Immunity in Old People. Gerontology 1983; 29:305-310. doi: 10.1159/000213131

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[19] Anitra C Carr, Balz Frei, Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans, The American Journal of Clinical Nutrition, Volume 69, Issue 6, June 1999, Pages 1086–1107, https://doi.org/10.1093/ajcn/69.6.1086

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[20] European Food Safety Authority. Scientific Opinion on the substantiation of a health claim related to zinc and normal function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/20061. EFSA Journal 2014;12(5):3653.